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Overall, these findings indicate that reductions in GPx3 abundance trends with disease severity with stage 1 having the highest mean levels of GPx3 (1.99 g/ml 0.73 g/ml) and the highest K1/U1 ratio (0.86), followed by the stage 2 with a mean of 1.2 g/ml 0.54 g/ml and average K2/U2 ratio of 0.67, with the most severe form of konzo, stage 3, displaying the largest reduction in average protein abundance (mean: 1.15 g/ml 0.58 g/ml) and the lowest K3/U3 ratio of 0.59 (Supplementary Data 1)

Selenoamino acid metabolism and fate of Se-cysteine (mineralization) towards activation of the Se-dependent GSH-Px system

This protective effect is linked to stabilization of cell membranes and preservation of intracellular homeostasis, allowing cells to maintain function during injury-related stress

Ethanol's suppression of GHRH and elevation of somatostatin mean that even though the peptides are present and biologically active, the pituitary's responsiveness is blunted

Abnormal glucose metabolism is closely linked to the PD pathogenesis and progression