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Erectile Dysfunction, Benign Prostatic Hyperplasia (BPH), Pulmonary Arterial Hypertension (PAH)

doi: 10.1016/j.biopsych.2015.07.028 199 LouZ.-Y.YuW.-B.ChenJ.LiL.JiangL.-S.XiaoB.-G.et al

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This enzyme converts ATP to cyclic AMP (cAMP), a crucial second messenger

Second, the high redundancy of intracellular signaling networks frequently triggers compensatory activation of alternative pathways, thereby diminishing therapeutic efficacy or even resulting in treatment failure