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Pro-inflammatory cytokines like interleukin (IL)-6, IL-1 and tumor necrosis factor-alpha (TNF-) can cause degradation of tight junction proteins and the endothelial glycocalyx through activated MMPs and trigger a reactive phenotype of microglia [167,168,169] (Fig
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[22] demonstrated a significant reduction in TPOAb levels following Se supplementation, particularly in those with Se deficiency
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