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R 6 is H, C 1 -C 6 alkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 7 heterocycloalkyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 3 -C 9 heteroaryl, optionally substituted C 1 -C 6 alkylC 6 -C 10 aryl, or optionally substituted C 1 -C 6 alkylC 3 -C 9 heteroaryl

Below, we outline some of the most notable preclinical and clinical studies related to AOD-9604's effects: In a 12-week clinical trial, participants administered 1mg/daily AOD-9604 experienced an average weight loss of 5.72lb, while the placebo group shed only 1.76lb

Brain Volume and Vessel Presentation Brain volume and vessel presentation were proportional to the change in the brain or vessel surface area

PubMed PMID: 6692038

however other interactions between cyclodextrins and insoluble compounds improve solubility