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Meanwhile, we measured the levels of lipid peroxidation, a key indicator of ferroptosis, and found that RSL3 treatment completely disrupted the protective effect of uridine (Supplementary Fig

From a mechanistic standpoint, luteolin affects multiple interconnected pathways including the Nrf2/ARE antioxidant pathway, NF-B and MAPK inflammatory cascades, PI3K/AKT/PTEN metabolic-survival signaling, TGF-/Smad fibrotic pathways, and ER/PR hormonal regulation (Thiruvengadam et al., 2021

doi: 10.1016/j.cgh.2006.08.008 221

(Lond.) 17 , 33 (2020)

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