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In addition, the absence of DHAR activity had no impact on the ascorbate profiles of the catalase-deficient mutant ( cat2 ) that maintains a highly oxidized glutathione pool

This is not proof of clinical harm at therapeutic doses, but it provides a plausible mechanistic basis for concern

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NAD+ NAD+ side effects can include: Flushing and warmth (especially during IV administration) Nausea or stomach discomfort Headache or dizziness Fatigue during initial treatment Muscle soreness or cramps These effects typically subside quickly, with most users experiencing minimal discomfort during treatment

One is the over-expression of GLS or GLS gene variant GLS-K325A leading to BPTES and CB-839 resistance in P493 lymphoma cell line and PC3 prostate cancer cell line respectively [58]

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