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The novel use of the internal reference, LR3, spiked into the analytical samples allows for the entire workflow of the assay, sample preparation to LC-MS/MS detection, to be monitored and provides quality assurance of the assay performance

Compounded medications are not FDA-approved drugs

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Notably, these changes correlate with decreased circulating GH and IGF-1 levels in female, but not male, rats

By bridging the target protein with an E3 ligase, PROTACs induce ubiquitination and subsequent proteasomal degradation of the target (Zeng et al., 2021)