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What the FDA Label and Guideline Documents Say The FDA prescribing information for evolocumab explicitly states: "Evolocumab is a human monoclonal antibody and is not expected to be metabolized by cytochrome P450 enzymes

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PMID: 30915550 Malinda KM, et al

BPC 157 ,

OncoImmunology 2 , e26744 (2013)

Ischaemic brain oedema