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Humans express a second betaine-homocysteine S-methyltransferase enzyme (BHMT2) that is encoded by the BHMT2 gene located in the same region of chromosome 5 (5q14.1) as the BHMT gene

Furthermore, the observation that sodium propionate supplementation effectively reduces serum ketone levels in ketotic cows validates the mediating role of rumen-derived propionate in the gutliver axis and ketosis 47

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However, some have not been sufficiently tested with humans at this point

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