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Recent investigations further indicated that UA may operate as a protective factor mediated through astroglia for dopaminergic neurons from glutamate toxicity ( + -induced depolarization amplifies neuroprotection provided by UA through a mechanism involving Ca 2 elevation and extracellular signal-regulated kinases (ERK 1/2 ) activation ( Figure 3 )

It can easily oxidise, turning into "oxidized glutathione," which is no longer effective for neutralising free radicals

Sisakhtnezhad S, Rahimi M, Mohammadi S (2023) Biomedical applications of MnO 2 nanomaterials as nanozyme-based theranostics

However, the spectrum exhibited an additional signal at m/z = 354 with high intensity, which corresponds to glutathione sulfonic acid GSO 3 H

Nonetheless, ongoing research and clinical use within cellular and regenerative medicine are steadily contributing to the broader understanding of these agents

Inaba H, Pan D, Shin YH, Martin W, Buchman G, De Groot LJ