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There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs

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These protective effects are associated with reduced hepatic and circulating free fatty acid levels, downregulation of inflammatory and immune response pathways, and suppression of hepatic PPAR signaling

In the present study, NIRS was used to evaluate the effects of l-carnitine on brain activity, which improved after 8 weeks of l-carnitine treatment in patients with cirrhosis

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ChIP of GPX4 promoter Chromatin immunoprecipitation (ChIP) was performed using a Chromatin Immunoprecipitation Assay Kit (ChIP Assay Kit, P2078, Beyotime) according to the manufacturers instructions