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Other risk factors with known health risks such as smoking cannot ethically be studied in a trial because some individuals would be randomized to engage in a behavior already known to be dangerous to one's health

That matters when you are working with compounds that cost significant money per vial and where dosing precision determines whether your research succeeds or fails

Draw your calculated dose using an insulin syringe (for example, 0.20 mL equals 500 mcg at this concentration)

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