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Comp Biochem Physiol C Toxicol Pharmacol (2009) 150(2):1016.10.1016/j.cbpc.2009.03.007 24 SadLBanniMKerkeniASadKMessaoudiI

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Use conditions We recommend taking 1 or 2 tablets of XINEPA a day after main meals

Shikonin activity can be inhibited by the inclusion of N-acetyl-L-cysteine, a known antioxidant and a precursor to GSH, which neutralizes ROS as part of the alternate glutathione synthase pathway, or through the over expression of TrxR itself (Duan et al., 2014)