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Figure 3 3.1 Inflammatory pathways mediated by gut dysbiosis Gut dysbiosis, characterized by an imbalance in microbial composition, compromises intestinal barrier integrity, leading to increased permeability

doi: 10.1016/j.ymgme.2013.03.011 162

However, depression is a complex condition with multiple contributing factors, and low BDNF alone is unlikely to be the sole cause

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Yamamoto, H., & Murphy, L.J

No matter which treatment method is used, it needs to be carried out on the basis of improving lifestyle, such as a light diet, rest, physical exercise, controlling weight, blood pressure, blood sugar, blood lipids, quitting smoking, and limiting alcohol