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Guarino, 1998

Dravet Syndrome is an NDD caused by haploinsufficiency of the SCN1A voltage-gated Na 2+ channel [72, 73]

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Besides, EpCAM overexpression is related to Wnt/-catenin pathway activation in cancers, which is a potential causal pathway for cytoplasmic and nuclear accumulation of -catenin, indicating proliferation and reduced apoptosis in cancer cells [141]

This pathway activation is also responsible for targeted therapy resistance in many cancer types [83]

Moreover, mast cells can directly influence adaptive immunity