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Titrating up from a lower starting dose is not glamorous, but it eliminates the majority of early complaints

Histidine (His): Contains an imidazole ring, key in biochemical reactions

Additionally, paclitaxel induces oxidative stress by increasing reactive oxygen species (ROS) production and nitric oxide, and decreasing antioxidant defenses, further exacerbating neuroinflammation (Duggett et al., 2016)

This allows for an obsessive level of quality control at every stage

LeWine, MD, Chief Medical Editor, Harvard Health Publishing

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