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The least mandibular growth increment at group 5-6 in our study also corroborated to the Gu et al

KDM6A/UTX KDM6A (UTX) also demethylates H3K27me3, promoting open chromatin and gene activation

The methylation pathway involves the SAM-dependent enzyme histamine N -methyltransferase which is encoded by the HNMT gene

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