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Stacked on top of insulin or a sulfonylurea it can, and the lever is de-intensifying that background drug, not lowering the tirzepatide dose. Over-loss in low-BMI deep responders Across the obesity trials, about 7% of participants fell below a BMI of 22, some by week 12

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The majority of the published literature examines each compound independently, and the synergy hypothesis, while mechanistically well-supported, has not yet been the subject of large-scale controlled studies

An echocardiogram may be arranged if a structural cardiac cause is suspected

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