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Tamouza H, Vende F, Tiwari M, Arcos-Fajardo M, Vrtovsnik F, Benhamou M, et al

and B.J

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[2] Free radicals can also cause negative feedback loops in the body, specifically a free radical chain reaction where one free radical binds to a molecule, generating another free radical, which then goes on to do the same

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We found that glutathione and thioredoxin, the major thiol antioxidants, and glutathione and thioredoxin reductases, the enzymes responsible for maintaining them in a reduced state, fell substantially in rodent bone marrow after ovariectomy and were rapidly normalized by exogenous 17- estradiol