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Current Opinion in Endocrinology, Diabetes, and Obesity, 29 (6), 554-559

Mathew John MD, DM

Studies of another thiol-containing antioxidant N -acetylcysteine (NAC), at its intrinsic pH, showed that it destabilizes the biofilm matrix by chelating divalent cations (e.g., Ca 2+ and Mg 2+ ), inhibition of bacterial extracellular polysaccharide production, modulation of bacterial cell physiology and the impact on its metabolism ( Our investigation of H 2 O 2 production by GSH during disruption and killing of MRAB biofilms produced interesting results (Figures 5CE)

However, the use of herbal drugs faces several limitations, such as toxicity, difficulty in extraction, low yield, standardization problems, complex dosage regimens, stability issues, and lack of specific targeting

gingivalis -triggered proinflammatory alveolar bone destruction in vivo and RANKL-associated osteoclasts development, stimulation, and metabolism in vitro (Gu et al., 2019)