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When used as a monotherapymeaning its taken on its own, without being combined with other medicationsits currently being tested in a large phase 3 clinical trial program called RENEW

In the Womens Health Study that followed nearly 40 000 women, 600 IU of supplemental vitamin E on alternate days, over approximately 10 years, reduced the risk of venous thromboembolism by 21% and pulmonary embolism by 28% compared with placebo

Further, a placebo-controlled trial in 152 elderly adults (aged 70-80 years) with mild cognitive impairment reported that B vitamin supplementation (50 mg/day of vitamin B 6 , 5 mg/day of folic acid, and 0.4 mg/day of vitamin B 12 ) for one year did not improve performance on a similar test of verbal fluency (136)

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[DOI] [PubMed] [Google Scholar] Ma, J