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4749 Given that the epistatic interactions presented here are key to folate-related thymidylate and methylation pathways, it seems likely that environmental factors such as UVR will prove to be an important determinant of disease occurrence in future studies

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They work through different pathways

discussion 45-16 Tze WJ, Sima AA, Tai J: Effect of endocrine pancreas allotransplantation on diabetic nerve dysfunction