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While low levels of reactive oxygen species (ROS) are crucial for homeostatic cellular signaling, elevated ROS levels over an extended period can harm neurons [2]

3) Patient-level factors that shift risk at a given dose Ethanol (acute and chronic): Chronic use induces CYP2E1 more NAPQI

Moradi M, Hashemian MA, Douhandeh E, Peysokhan M, Hashemian AH, Faramarzi A

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Shive W, Pinkerton F, Humphreys J, Johnson MM, Hamilton WG, Matthews KS (1986) Development of a chemically defined serum- and protein-free medium for growth of human peripheral lymphocytes