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Originally identified by Loren Pickart in human plasma, GHK-Cu has been the subject of extensive cellular biology and biochemical research literature for over five decades, with research contexts examining tissue biology, cellular signaling pathways, copper-binding peptide chemistry, and extracellular matrix research

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Individuals with irritable bowel syndrome (IBS) exhibit elevated levels of bacteria related to intestinal inflammation, such as Enterobacteriaceae and Streptococcus , while the content of beneficial bacteria (such as Faecal Streptococcus ) decreases (Sciavilla et al., 2021)