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doi: 10.1016/j.parkreldis.2016.08.019 252 LiuJLvXYeTZhaoMChenZZhangYet al

In patients with critical peripheral limb ischemia (n = 10, age 68.3 3.1), a single intravenous dose of L-arginine significantly increases blood flow, accompanied by urinary cGMP excretion ( Overall , intravascular L-arginine delivery in humans offers acute improvement of endothelial function