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Insulin resistance is one of the leading causes of aging, and improving insulin sensitivity may help slow down the aging process

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Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL (1999) Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

( E ) Representative Western blots show decreased expression of GPX4 under conditions of 15LO1 inhibition ( n = 4)

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While some individuals report positive results after weeks to months of treatment, the temporary nature of effects, lack of regulatory approval, and documented adverse events warrant careful consideration