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Although the magnitude of hydraulic resistance experienced by migrating breast cancer cells in vivo is currently unknown, mathematical modeling indicates that depending on the interstitial fluid viscosity and matrix permeability, the hydraulic resistance within 3D matrices could potentially match or even exceed that observed in microchannels [50, 203]

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In this regard, precise screenings for personal and family history of thromboembolic events, stroke, and heart disease should be considered prior to therapy initiation (Lee et al., 2016a)