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Inactivation of one pathway can compensate for the other pathway, and both pathways inactivated can trigger mitochondrial lipid peroxidation

Steel DM, Whitehead AS

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In clinical use, children with extensive thermal burns who were treated with IGF-I in combination with IGFBP-3, presented a reduction in serum levels of IL-1, TNF-, C-reactive protein, 1-acid glycoprotein, and complement C-3[299]

Signal Transduct Target Ther 8(1):217 Qin L et al (2024) New advances in the diagnosis and treatment of autism spectrum disorders