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Are there clinical features of liver disease, myeloproliferative disorder (e.g., blood film changes of unexplained cytopenia, thrombocytosis, or leukocytosis), or another cancer (e.g., cachexia, constitutional symptoms fever, weight loss, night sweats)

Species-specific factors profoundly influence both efficacy and safety profiles

Potential Benefits (preclinical) Fat metabolism: Animal models report reductions in fat mass while lean muscle is preserved [5] [6]

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If no adverse effects occur, increase to 300-500mcg for the remainder of the cycle

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