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Supplementing C

539 Genetic and pharmacological inhibition of TDO and KMO can increase KYNA, but not the level of neurotoxic product 3-HK, thereby improving the symptoms of neurodegeneration

Krizhevsky, A., Sutskever, I

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Recent longitudinal imaging studies suggest that loss of medial frontal cortical grey matter may occur within the few weeks preceding of the transition from the prodrome to psychosis [5], which would be consistent with synaptic loss due to excitotoxic damage or excessive pruning in early illness