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Unfortunately, its levels are often lower than they should be and the factors contributing to it are mostly poor diet and malnutrition, chronic stress, age, toxins, and overall inflammation

Drug Metab Rev 1998, 30 (2), 245275

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Our professional observation is this: while theoretically plausible, it requires an extraordinary level of caution and a deep, nuanced understanding of endocrinology

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Gelenberg AJ, Chesen CL