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PHGDH is the rate-limiting enzyme for de novo serine synthesis, catalyzing the conversion of D-3-phosphoglycerate to 3-phosphohydroxypyruvate, the first critical step in serine biosynthesis [90,91]

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Of note is that MTs have been effective in reversing many aspects of DCM, and the overexpression of MTs has efficiently reduced the degree of cardiac damage [23]