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GI dysfunction, a common comorbidity in PD, further contributes to fluctuations in levodopa absorption and plasma concentrations, thereby triggering or exacerbating the on-off phenomenon [86, 87]
Orforglipron, a non-peptide GLP-1 receptor agonist, represents another daily oral incretin-based AOM displaying dose-dependent BW and WC reductions at 36 weeks ranging from 9.4 to 14.7% and from 9.6 cm to 13.6 cm with the 12 and 45 mg dose, respectively, in mostly female (59%) patients with a mean age of 54.2 years and BMI 37.9 kg/m 2 44
Additionally, disruptions in the balance between excitatory neurotransmitters like glutamate and inhibitory neurotransmitters like gamma-aminobutyric acid (GABA) can further exacerbate depressive symptoms
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doi: 10.3390/ani11061609 33