A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
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When NNMT is overactive, it consumes excess NAD+, leaving less available for these critical processes
Occur in 3050% of subjects during dose titration
There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses
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