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The microbiotagutbrain axis and its potential therapeutic role in autism spectrum disorder

Proc Soc Thorac Surg, 2000

The potential mechanism of polysaccharide-targeted intervention in depression through tryptophan metabolism is illustrated in Figure 5

The pH value of the TME is typically 10 to 30 times higher than that of normal tissues 45

10.3390/pharmaceutics10030116 61 GBD 2021 Nervous System Disorders Collaborators (2024)

Moreover, ROS can directly target ETC complexes, especially complex I and complex III, causing electron leakage and amplifying ROS production, which further intensifies oxidative stress and mitochondrial dysfunction [26]