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Furthermore, autistic individuals often exhibit disturbances in redox signaling, with reduced levels of reduced glutathione and an increase in oxidized glutathione disulfide
TFEB activators, such as rapamycin, reverse the age-related decline in autophagy-lysosomal function, and overexpression of HLH-30 prolongs the lifespan of C
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The oxidized glutathione is then reduced by glutathione reductase (GR) and b-nicotinamide adenine dinucleotide phosphate (NADPH) forming NADP+ (resulting in decreased absorbance at 340 nm) and recycling the GSH