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First identified as a factor which regulates the expression of the immunoglobulin light chains in B lymphocytes [57] NF-B is also recognized as a sequence-specific transcription factor involved in the activation of an exceptionally large number of genes in response to inflammation, viral and bacterial infections, and other stressful situations requiring rapid reprogramming of gene expression, such as oxidative challenge [54, 55]

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It is a powerful inhibitor of neutrophil elastase and chemotaxis [184] and was recently granted an international Patent Publication [185]

Additionally, our results suggested that the prothrombotic effects of folate deficiency depend on an increase in circulating homocysteine

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