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Single, double and triple knockout mutants for DHAR have been reported (Noshi et al

Beyond proteasomal targeting, non-canonical ubiquitin modifications, including K63-linked polyubiquitination, regulate signaling, endocytosis, kinase activity, and DNA damage responses, while mono- and multi-ubiquitination influence chromatin dynamics, DNA repair, and subcellular localization (Fig

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The AUDIT questionnaire (Alcohol Use Disorders Identification Test) was given to determine if there was alcohol abuse

The latter is quite stable, and may accumulate during GSH depletion, because GSH is needed to regenerate the selenolate (14)

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