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Many studies have been carried out in the recent decades, in vivo and in vitro, as it is significant to know how the placenta functions both as a transport region and as a place of metabolism of diverse drugs and chemicals, which helped the scientific community to understand the mechanisms of transport and metabolism through the placenta, while the development of the ex vivo placental perfusion method gave us a significantly clearer picture of the toxicokinetics of the placenta [133]

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