Craig 2010), accounting for more than 56,000 emergency room visits, 26,000 hospitalizations, and 450 deaths per year in the U.S
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Some toxicity can be mitigated by the concomitant administration of folic acid
The timepoint chosen (when drug-tolerant cells are emerging after treatment) probably contributes to this effect, and later timepoints (when cells perhaps enter senescence or other more terminally arrested states) are more likely to reflect the expected gene expression patterns
43 Likewise, among developing countries, the Korea NHANES reported that the prevalence of hyperuricemia in Korea was 11.4% with 17.0% in male and 5.9% in female
