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doi:10.1002/jssc.200500027

Neither one is currently available in Australia

An in vitro study was undertaken to investigate the anticancer effects and mechanisms of action of methotrexate (MTX) in conjunction with vitamin E variants (tocopherol) and derivatives (tocopherol succinate) on triple-negative breast cancer (TNBC) (123)

glutathione is likely to be oxidised by the burst of ROS released from over-reduced electron transport components and metabolic NADP reduction can re-commence due to oxygen-dependent metabolic flux through the relevant enzyme systems such as those of the cytosolic oxidative pentose phosphate pathway

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However, results of these studies do not reflect the dramatic and consistent data demonstrated in animal studies