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Moreover, following HQ treatment, N-acetylcysteine butyl ester (NACBE) protected RPE cells from cellcell junction disruption and, in general, ester derivatives of NAC prevented mitochondrial oxidative damage, measured as mitochondrial depolarization, even better than MitoQ, a well-known mitochondrial-targeted antioxidant

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The resulting Cre+, G0s2 fl/fl mice were bred to G0s2 fl/fl mice to generate G0s2 Ad-cKO experimental mice and G0s2 fl/fl littermate controls