Escherichia coli , Akkermansia muciniphila , and Faecalibacterium prausnitzii contribute to improving intestinal serotonin balance through the regulation of serotonergic genes ( Escherichia coli secretes -glucuronidase, which facilitates the conjugation of serotonin with glucuronic acid to form the water-soluble metabolite 5-hydroxytryptophan glucuronide (5-HTG), thereby enhancing its excretion ( Clostridium scindens upregulates monoamine oxidase A (MAO-A) activity, promoting the oxidative deamination of serotonin into the inactive metabolite 5-hydroxyindoleacetic acid (5-HIAA) ( Lacticaseibacillus rhamnosus (basonym Lactobacillus rhamnosus ), Lactobacillus acidophilus , and Lactiplantibacillus plantarum (basonym Lactobacillus plantarum ), not only facilitates the metabolic conversion of tryptophan to serotonin but also suppresses MAO-A activity via the secretion of short-chain fatty acids (SCFAs), thereby enhancing serotonin bioavailability through dual mechanisms ( 3.2.2 Regulation of -aminobutyric acid -aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain and plays a critical role in maintaining neural excitability balance
Another study that includes 33 children diagnosed with ASD received an average daily CBD-enriched cannabis dose of 0.7 mg/kg/day for an average of 6.5 months
Boosts Immunity It supports your immune system, helping you fight off seasonal illnesses
Malihi Z, Wu Z, Stewart AW et al (2016) Hypercalcemia, hypercalciuria, and kidney stones in long-term studies of vitamin D supplementation: a systematic review and meta-analysis
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TongHYangTXuSLiXLiuLZhouGet alHuntingtons disease: complex pathogenesis and therapeutic strategies
