Lasting Remodeling: Gene expression changes produce sustained collagen rebuilding that develops over weeks to months rather than delivering only transient effects
The next paragraphs will discuss genetic predisposition and susceptibility as an underlying risk factor for ME/CFS - the superimposition of external stressors and exposures (59) results in a state of aberrant homeostasis, where a temporary homeostatic state of functioning occurs, but functions at a less optimum level (64)
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As illustrated in Figure 3, pro-inflammatory cytokines, including TNF-, IL-1, and IL-6, promote OA progression by activating signaling intermediates such as p38 and ERK1/2, leading to upregulation of matrix metalloproteinases (MMPs) and degradation of cartilage structure
SERM, selective estrogen receptor modulator
Fasting glucose and insulin: If you have access to a continuous glucose monitor or regular labs, MOTS-C's effects on insulin sensitivity are measurable