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These monotherapy results established proof of concept that amylin receptor agonism alone can produce clinically meaningful weight reduction and informed the dose selection of 2.4 mg for the combination product CagriSema

User 12 used 500mcg daily and was specifically trying to determine whether splitting that dose or taking it all at once produced better results

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TB-500 sits at the bioactive Ac-SDKP tetrapeptide fragment level, and the three supporting components at 10mg each provide concentration parity for pathway interaction studies without the dominant component being diluted below practical research thresholds