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Other groups have reported increased efficacy with 5FU and metformin in models of acquired resistance 53,54,55,56 , in spheroid culture 53 or xenograft/PDX models 57,58,59 , but the potential of combined 5FUCI inhibitor co-treatment in a chemo-naive, immune-competent setting requires further investigation

High-dose vitamin D 3 supplementation in ventilated, critically ill patients decreases length of hospital stay [113]

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Macinnis et al., 2017), a dissociation between these two parameters has been previously reported in humans (Granata et al., 2016

Whilst live virus vaccines remain in use, antivirals may also be required after polio eradication to control outbreaks of circulating vaccine-derived polioviruses 19,20