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Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

This potential result coincides with signs of both increased fat breakdown and reduced fat accumulation

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Its substrate site-targeting mechanism inhibiting NNMT at the nicotinamide binding site provides selectivity over related methyltransferases and other enzymes in the NAD salvage pathway, making it a precise tool compound for studying NNMT-specific enzymatic activity in controlled laboratory systems

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1996;126(3):756S-760S