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The compound was developed by the Australian biotech firm Metabolic Pharmaceuticals as a research tool to isolate the lipolytic signaling domain of growth hormone without the receptor-binding region responsible for its anabolic and glucose-handling effects

Lipids 1483 , 3757 (2000)

The physiologic and metabolic effects of perilipin ablation in mice support this idea

During the study, one patient died and another was hospitalized, but these events were not considered related to study participation

These TF act as epigenetic regulators of chromatin structure through interactions with histone modifiers, chromatin remodeling complexes, transcriptional regulators, and/or DNA methylation machinery that modulate gene expression