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PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake

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As of now, CagriSema is still in clinical trials and not yet approved for general use

Below is a full breakdown of what separates the two

Elsevier, Oxford, pp 175215 Rausch S, Gouttefangeas C, Hennenlotter J, Laske K, Walter K, Feyerabend S, Chandran PA, Kruck S, Singh-Jasuja H et al (2019) Results of a phase 1/2 study in metastatic renal cell carcinoma patients treated with a patient-specific adjuvant multi-peptide vaccine after resection of metastases

To extend stability, peptide solutions are often stored in sterile buffers with a pH around 56 and kept at -20C or colder when appropriate