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33 , 34 After oral administration, absorption of glutathione is very poor mainly due to hydrolysis by intestinal and hepatic -glutamyltransferase as mentioned above, and for that reason, most therapeutic approaches using the oral route struggle to achieve results and the patients seek less safe treatments like intravenous treatment often under uncontrolled situations which may not be medically supervised, in some countries

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Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ

Monreal Santiago, G., Liu, K., Browne, W

The brain consumes a massive amount of oxygen and is highly susceptible to oxidative stress, which manifests clinically as severe brain fog, memory impairment, and neuroinflammation